ALS Center of Excellence

Pranger ALS Clinic

  • Home
  • About
    • What Is ALS?
    • Scott L. Pranger
    • National Advisory Board
    • Faculty & Staff
    • ALS Center of Excellence Brochure
  • Clinic
    • Services
    • Your Visit to the ALS Clinic
    • Patient Portal
    • Durable Medical Equipment
    • Frequently Asked Questions
  • Research
    • Clinical Trials
    • Observational Studies
    • Participate in Research at U-M
  • News
  • Patient Care Guide
    • Living with ALS
    • Nutrition
    • Patient & Family Support
  • Contact
  • NeuroNetwork
  • Make A Gift

Latest News

ALS Risk Higher Among Production Workers

… [Read More...]

“Research Into Preventing ALS…”

… [Read More...]

portrait of Dr. Eva Feldman in her lab

Dr. Feldman Given Highest University of Michigan Honor

… [Read More...]

Multidisciplinary Team Publishes Paper on ALS Occupational Risk

… [Read More...]

The ANA Q&A: Dr. Eva Feldman on ALS

… [Read More...]

U-M Collaborator Lab Wins ALS Research Challenge

November 17, 2020

Congratulations to the Nesvizhskii Lab’s “Team MSFragger Swagger.”

Kevin (top center) led the team to victory in identifying protein post-translational modifications (PTMs) related to ALS. Team MSFragger Swagger: Fengchao Yu, Daniel Geiszler, Hui-Yin Chang, Dan Polasky, Sarah Haynes, Kevin Yang.

Dr. Alexey Nesvizhskii’s laboratory from the University of Michigan Department of Computational Medicine and Bioinformatics recently won the #ALSMinePTMs challenge, which was put on by News in Proteomics Research. The goal of the data mining challenge was to reanalyze an amyotrophic lateral sclerosis (ALS) dataset from 2018 to identify new post-translational modifications (PTMs) on proteins in cerebrospinal fluid samples.

Led by Bioinformatics Ph.D. students Kevin Yang and Daniel Geiszler, the Nesvizhskii lab competed against more than 30 teams spread across the United States (including: Johns Hopkins University, Massachusetts Institute of Technology, University of Pennsylvania) and around the world (including: Australia, Israel, Switzerland).

The Nesvizhskii lab earned first place for its detection of several differentially expressed modified proteins between ALS and healthy samples. The lab also searched the literature and found some preliminary evidence that these PTMs could be linked to biological mechanisms like aging or oxidative stress, but follow-up wet lab studies are necessary before making further conclusions. The lab intends to write a scientific paper that summarizes its findings as a result of the #ALSMinePTMs challenge.

Read more at News in Proteomics Research.

Share this:

  • Facebook
  • Twitter
  • LinkedIn

Filed Under: News

Newsletter Signup

Subscribe to our mailing list for updates regarding our clinic and research

Click Here for the ALS Registry

ALS Center of Excellence at Michigan Medicine ALS Infographic

ALS Brochure

ALS Brochure

 

 

 

 

 

Resources

Organizations

  • ALS Association
  • ALSA-Michigan Chapter
  • Ann Arbor Active Against ALS
  • ALSA-Northern Ohio Chapter
  • ALS of Michigan
  • National ALS Registry
  • Northeast ALS Consortium
  • Muscular Dystrophy Association

Services

  • Veterans Benefits
  • Social Security Benefits

Useful Links

  • U-M Stem Cell Research
  • Center for Stem Cell Biology
  • Human Embryonic Stem Cell Research
  • Society for Stem Cell Research

RSS Research News

  • U-M to establish new Institute for Firearm Injury Prevention
  • U-M Depression Center to be named for Eisenberg family, in recognition of $30M in giving
  • Research on aging expands at U-M with $15M in new grants

Contact Information

Michigan Medicine
1500 E. Medical Center Drive
Ann Arbor, MI 48109
Phone: 734-936-4000
Contact Michigan Medicine

Connect With Us

Copyright © 2023 Regents of the University of Michigan · Disclaimer · Privacy Statement

  • About UMHS
  • For Patients
  • For Health Professionals
  • For Researchers
  • Home
  • About
    ▼
    • What Is ALS?
    • Scott L. Pranger
    • National Advisory Board
    • Faculty & Staff
    • ALS Center of Excellence Brochure
  • Clinic
    ▼
    • Services
    • Your Visit to the ALS Clinic
    • Patient Portal
    • Durable Medical Equipment
    • Frequently Asked Questions
  • Research
    ▼
    • Clinical Trials
    • Observational Studies
    • Participate in Research at U-M
  • News
  • Patient Care Guide
    ▼
    • Living with ALS
    • Nutrition
    • Patient & Family Support
  • Contact
  • NeuroNetwork
  • Make A Gift